AltSplice Mapper

Developed by Barry van der Mast


Introduction

Alternative Splice Mapper or AltSplice Mapper generates a list of possible alternative spliced genes based on an exon microarray expression data table. The program normalizes (normalized intensity), calculates a SI (splicing index) and ECSI (expression corrected splicing index) value for every probeset expression level. With cutoff options taken from the user; gain, loss, ratio and ends/middle interval percentages the program returns possible splicing events in various output formats.

The program collects the exon expression data for one transcript. After normalization the program determines whether these are outliers in exon expression among the different samples provided. Using custom cutoff values, candidate alternative spliced transcripts, alternative promoters or potential fusion genes can be identified.

Downloads:

AltSplice Mapper 1.00 2009
ManualPdf file
Program Includes AltSplice Mapper.py, ASM_MainApp.py, Transcript.py and
erasmuslogo1.jpg. Run AltSplice Mapper.py to start the program! 		 ZIP file
Python source code Contains a setup for Python 2.6.1 installer for Windows XP.
Updated Python code may cause script to return errors.		 MSI file
WxPython source code Contains a setup for WxPython 2.8 installer for Windows XP.
Updated WxPython code may cause script to return errors.
WxPython cannot be used on Windows Vista.
Please let me know of any bugs and alterations to my script via e-mail		 MSI file

Example input files:

Test File 1 Tab delimited
Test File 2 Tab delimited
Test File 3 Tab delimited



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Page Last Updated : Mon, 3 Mar 2009 16:07:26 +0100